Oxytetravet 20%
...DESCRIPTION
Oily liquid from yellow to reddish-yellow color.
COMPOSITION
Each 1 ml contains the active ingredient:
Oxytetracycline hydrochloride – 200 mg.
Excipients: 1,2 - propylene glycol, lidocaine hydrochloride, water for injections.
PHARMACOLOGICAL PROPERTIES
ATCvet classification code QJ01 - antibacterial veterinary medicines for systemic use. QJ01AA06 - Oxytetracycline.
Oxytetracycline – an antibiotic that belongs to the group of tetracyclines.
The mode of action is inhibition of protein synthesis by binding to 30S ribosomal subunit of microorganisms that susceptible to oxytetracycline, thereby preventing the connection between ribosomes and aminoacyl-tRNA. It’s also believed that oxytetracycline inversely connects with 50S ribosomes and changing the permeability of the cytoplasmic membrane of the sensitive microorganisms. Oxytetracycline, at high concentrations, can also inhibit protein synthesis in cells.
The medications has a broad spectrum of action on gram-positive and gram-negative microorganisms: Streptococcus spp., Clostridium spp., Corynebacterium spp., Brucella spp., Haemophilus spp., E. coli, Pasteurella spp., Klebsiella spp., Erysipelothrix spp., Fusobacterium spp., Salmonella spp., as well as the simpliest (Protozoa), mycoplasma (Mycoplasma spp.), rickettsia (Rickettsia spp.) and chlamydia (Chlamydia).
After injecting the medication, tetracycline is getting gradually absorbere.
The half-life in dogs is approximately 4-6 hours, 4,3-9,7 hours - in cattle, 6.7 hours - pigs, 3.6 hours - in sheep.
Oxytetracycline penetrates practically into all organs and tissues, but the highest level occurs in the lungs, liver, bile, reproductive organs and in the kidneys. At low concentrations, oxytetracycline appears in the cerebrospinal fluid, but its concentration does not reach therapeutic levels. Oxytetracycline does not form metabolites. It is excreted with urine and bile as well as with milk.
INDICATIONS
Treatment of cattle, sheep, goats, pigs and dogs that suffering from bronchopneumonia, pleuropneumonia, enteritis, septicemia, mastitis, metritis, ungulates rot, mycoplasmosis, chlamydiosis and diseases of the respiratory and urogenital systems, gastrointestinal tract, which caused by pathogens sensitive to oxytetracycline.
DOSAGE
Intramuscularly at following doses:
Cattle, sheep, goats, pigs, calves – 1.0 ml of the preparation per 10 kg of body weight;
Dogs – 0.5 ml of the preparation per 10 kg of body weight.
Apply every 48 hours, for 3 - 5 days, depending on veterinarian’s instructions.
CONTRAINDICATIONS
Do not use for animals with hypersensitivity to oxytetracycline, and animals with renal and hepatic impairment.
Do not use concurrently with antibiotics with bactericidal action, such as penicillin, or with non-steroid anti-inflammatory agents.
Do not use in horses.
PRECAUTIONS
Animals may only be slaughtered for meat and milk may be used in food after 12 and 4 days respectively, after the last injection.
HOW SUPPLIED
Neutral glass vials of 10-mL, 20-mL, 50-mL,100-mL and 200 mL, closed by a rubber stopper and sealed with an aluminum cover. Secondary package: carton box.
STORAGE
Dry, dark, inaccessible to children place at temperature from 5°C to 25°C.
Shelf life – 2 years.
After opening, the preparation should be used within 14 days, and stored in a dark place at temperature from 0 to 5°C.