Gentazimvet (water soluble powder)
...DESCRIPTION
White to greyish powder with a specific odor of its components.
COMPOSITION
1 g contains the active ingredients:
gentamicin sulphate – 40.0 mg
sulfadimidine – 100.0 mg
trimethoprim – 20.0 mg
PHARMACOLOGICAL PROPERTIES
Gentazimvet is a combined preparation of gentamicin sulphate, sulfadimidine and trimethoprim. As a result of synergy of active substances, the activity of the preparation is much higher than its individual components.
Gentamicin – an antibiotic that belongs to the group of aminoglicosides. It is active against gram-negative and gram-positive microorganisms: Escherichia coli, Salmonella spp., Shigella spp., Enterobacter aerogenes, Klebsiella spp., some species of Proteus spp. and Serratia spp., Pseudomonas aeruginosa, Pasteurella multocida, Starhylococcus aureus, Serpulina hyodysenteriae, Mycoplasma spp.
The mechanism of action of the preparation is to block protein synthesis in bacterial cells.
Sulfadimidine and trimethoprim are bacteriostatic against gram-positive and gram-negative microorganisms (Starhylococcus spp., Streptococcus spp., Clostridium spp., Listeria monocytogenes, Corynebacterium spp., E.coli, Salmonella spp., Klebsiella spp., Proteus spp., Pasteurella spp., Bordetella spp. etc.).
Their mechanism is consistent inhibition of enzymes involved in the synthesis of folic acid, thereby inhibiting the synthesis of bacterial cell tymidine. Sulfadimidine blocks the conversion of para-aminobenzoic acid to dihydrofolic and trimethoprim blocks the conversion digidrofolic acid in tetrahydrofolic acid by inhibiting dihydrofolate reductase.
INDICATIONS
Calves, lambs and kid-goats less than 3 months old – treatment of animals suffering from pasteurellosis, mycoplasmosis, dysentery, salmonellosis, pneumonia caused by organisms sensitive to the components of the preparation.
Pigs – treatment of animals suffering from dysentery, pneumonia, erysipelas, colibacillosis, salmonellosis, pasteurellosis caused by microorganisms sensitive to the components of the preparation.
Dogs, cats – treatment of animals with diseases of the respiratory and alimentary canals caused by organisms sensitive to the components of the preparation.
Hens Broilers, Turkeys – treatment of birds sick with salmonellosis, pasteurellosis, and respiratory diseases caused by microorganisms sensitive to the components of the preparation.
DOSAGE
Orally in doses:
Calves – 1 g of the preparation per 10 kg of body weight;
Lambs and kid-goats – 1 g of the preparation per 10 kg of body weight;
Pigs – 1 g of the preparation per 10 kg of body weight;
Dogs, cats – 1 g of the preparation per 10 kg of body weight;
Poultry (chicken-broilers, turkeys) – 1 g of the preparation per 2.5 – 2.8 kg of feed.
The preparation is used with the intervals 24 hours, treatment course 3 – 5 days.
CONTRAINDICATIONS
Hypersensitivity to gentamicin, and trimethoprim sulphadimezin.
Do not use for animals in lactating period and animals with impaired renal function, hearing and balance.
Do not use simultaneously with other aminoglycosides and antibiotics with nephrotoxic effect (polymyxin B, colistin, amphotercin, chloramphenicol, cephalospirin, erythromycin).
Do not administer to laying hens producing eggs for human consumption.
Do not use for treatment of hunting and service dogs, in connection with a possible lesion vestibular and hearing.
PRECAUTIONS
Animals may only be slaughtered for meat 7 days after the last treatment and for milk – after 4 days.
HOW SUPPLIED
Packed with polyethylene pellicle of 1g, 50 g, 500g and 1 kg.
Polymer containers of 100g and 500 g, 1 kg.
STORAGE
Dry, dark, inaccessible to children place at temperature from 5°C to 25°C.
Shelf life – 3 years.