Gentavet 4% solution
...DESCRIPTION
Transparent colorless solution.
COMPOSITION
Each 1 ml contains the active ingredient:
gentamicin sulphate – 40 mg.
PHARMACOLOGICAL PROPERTIES
ATCvet QJ01 - antibacterial veterinary medicines for systemic use (QJ01GB03, Gentamicin).
Gentamicin – an antibiotic that belongs to a group of aminoglycosides. Its mechanism of action is in violation of bacterial protein synthesis by binding to the 30S-subunit of the bacterial ribosome. Under these conditions, it’s observed the formation of a protein with irrelevant amino acid sequence.
It is active against the gram-negative and gram-positive microorganisms: Escherichia coli, Salmonella spp., Shigella spp., Enterobacter aerogenes, Klebsiella spp., some species of Proteus spp. and Serratia spp., Pseudomonas aeruginosa, Pasteurella multocida, Starhylococcus aureus, Serpulina hyodysenteriae, Mycoplasma spp.
The mechanism of action is to block protein synthesis in bacterial cells.
Resistance to it is rare and slow to develop.
The maximum drug concentration in blood serum is observed one hour after administration. Therapeutic concentrations stored in the body 8 to 12 hours. Gentamicin is also penetrating into the pleural and peritoneal cavity and placenta. In the active form excreted by the kidneys.
INDICATIONS
Cattle, horses, pigs, dogs, cats: treatment of animals suffering from septicemia, arthritis, also from diseases of gastrointestinal tract (gastritis, enteritis, peritonitis), respiratory organs (tonsillitis, tracheitis, pneumonia, bronchitis, bronchopneumonia) and genitourinary system (nephritis, pyelitis, pyelonephritis, urethritis, urocystitis, metritis, mastitis), skin (dermatitis) caused by pathogens susceptible to gentamicin.
Chickens, turkeys, ducks, geese: treatment of poultry suffering from septicemia, colibatcilosis, pasteurellosis, salmonellosis caused by pathogens susceptible to gentamicin.
DOSAGE
Intramuscularly with intervals 8-12 hours in following doses:
cattle – 0,5-1,25 ml of the preparation per 10 kg of body weight;
horses – 0.5-1ml of the preparation per 10 kg of body weight;
pigs – 0.5-1 ml of the preparation per 10 kg of body weight;
dogs, cats – 1.25 ml per 10 kg of body weight.
Subcutaneously with interval 8-12 hours in doses:
poultry (chickens, turkeys, ducks, geese) – 0.05 ml per 1 kg of poultry weight.
Treatment period 3 – 5 days.
CONTRAINDICATIONS
Hypersensitivity to gentamicin.
Do not use in animals with impaired renal function, hearing and balance.
Do not use simultaneously with other aminoglycosides and antibiotics with nephrotoxic effect (polymyxin B, colistin, amfotercin, chloramphenicol, cephalosporin, ritromycin), also with muscle relaxants and anesthetics, sulfonamides, heparin, B vitamins, diuretics (furosemide).
Do not administer to laying hens producing eggs for human consumption.
PRECAUTIONS
Animals may only be slaughtered for meat 45 days after the last treatment and for milk – 3 days.
Poultry may only be slaughtered for meat 14 days after the last treatment.
HOW SUPPLIED
Neutral glass vials of 10-mL, 20-mL, 50-mL and 100-mL, closed by a rubber stopper and sealed with an aluminum cover. Secondary package: cartons.
STORAGE
Dry, dark and inaccessible to children place at temperature from 5°C to 25°C.
Shelf life – 2 years.
After the first selection from the vial, the medicine should be used within 14 days, provided storage in a dark place at a temperature of 0°C to 5°C.