Flumeq
...DESCRIPTION
A white powder.
COMPOSITION
1 g of the preparation contains the active ingredient:
Flumequine – 500 mg.
Excipients: Sodium carbonate.
PHARMACOLOGICAL PROPERTIES
Flumequine is a synthetic fluoroquinolone antibiotic.
Flumequine has a broad spectrum of antimicrobial action.
The mechanism of antimicrobial action is due to inhibition of the active enzyme of DNA-gyrase, which is a major factor in the catalysis of DNA synthesis in the nucleus of the microbial cells, resulting in rapid bactericidal effect.
Flumequine is active against gram-negative Е. coli, Salmonella spp., Proteus spp., Pseudomonas spp., Klebsiella spp., Aerobacter spp., Pasteurella spp., Bordetella spp., Haemophilus spp., Enterobacter spp., Vibrio spp., Cytophaga spp., and gram-positive bacteria of the genus Staphylococcus spp. and Diplococcus spp.
After oral administration, flumequine is rapidly and almost completely absorbed (80%) in young ruminants. In adult ruminants, its absorption in the digestive tract is insignificant (about 10%). flumequine achieves the optimal therapeutic concentrations in blood plasma and tissues after 30 minutes after application.
After intake 12 mg per 1 kg of body weight, flumequine reaches its optimal therapeutic concentration in blood plasma and soft tissues within half an hour. The peak concentration in the plasma is observed in less than 2 hours.
APPLICATION
Calves (4 to 8 weeks old) and pigs: treatment of animals suffering from enteritis, salmonellosis, as well as respiratory diseases caused by microorganisms sensitive to flumequine.
Poultry (broilers, young poultry, turkeys, geese, ducks): treatment against colibacillosis, salmonellosis, pasteurellosis caused by microorganisms sensitive to flumequine.
INDICATIONS
Orally with feed, drinking water or milk substitute, for 3-7 days, at the following doses:
Calves (4 to 8 weeks old): 0.5-1 g per 50 kg of body weight twice a day.
Pig: 0.5-1 g per 50 kg of body weight, or 100-200 g per 1000 liters of drinking water twice a day.
Poultry (broilers, young poultry, turkeys, geese, ducks): 200-400 g per 1000 liters of drinking water twice a day.
CONTRAINDICATIONS
Do not use in animals with hypersensitivity to flumequine.
Do not use concurrently with trimethoprim, sulfonamides, furoxin, hydrocortisone and phenylbutazone.
Do not use in animals with functionally developed proventriculus.
Do not use in laying hens producing eggs for human consumption.
PRECAUTIONS
Slaughtering of animals (calves and pigs) for meat is permitted after 5 days from the last treatment, for poultry – after 3 days.
HOW SUPPLIED
Polyethylene packets of 1, 10, 50, 100, 500 g, and 1, 20, 25 kg.
Containers of 100, 500 g. and 1 kg.
STORAGE
In a dark, dry place, at 15°C – 25°C.
Keep out of the reach of children, animals and food.
Shelf life: 3 years.