Amoxyvit
Amoxicillin belongs to the group of β-lactam antibiotics. It blocks the synthesis of cellular walls of the bacteria, inhibits the activity of the enzyme transpeptidase and carboxypeptidase, causes a disturbance of the osmotic balance, leading to the death of the microorganisms during its growth.
The preparation is active against Gram-positive microorganisms (Bacillus antracis, Cloctridium spp., Corynebacterium spp., Erysipelothrix rhusiopathiae, Streptococcus spp., Staphylococcus spp., Leptospira spp., Listeria monocytogenes) and Gram-negative microorganisms (Actinobacillus spp., Bordetella bronchiseptica, Fusobacterium spp., Haemophilus spp ., Moraxella spp., Pasteurella spp., Proteus mirabilis, Salmonella spp.) and other pathogens that are susceptible to amoxicillin.
After intramuscular administration amoxicillin is rapidly absorbed into the blood and is distributed in most tissues and body fluids. During the meninges inflammation concentration of the drug in cerebro spinal fluid may be up to 30-60% of the concentration in serum.
Amoxicillin is deduced unchanged mainly through kidneys by tubular secretion, but a small portion is metabolized by hydrolysis to inactive the penicillin acid and excreted in the urine.